DOI Aktif
Peluang Terapi Metformin Selain Sebagai Obat Diabetes
KATA KUNCI
Metformin, diabetes tipe 2, terapi alternatif, anti kanker, anti-inflamasi, PCOS
Rp 60.000
Rp 30.000
Metformin dikenal luas sebagai terapi utama untuk diabetes tipe 2. Namun, penelitian terbaru menunjukkan bahwa metformin juga memiliki potensi terapeutik yang menjanjikan di luar itu, seperti sebagai agen anti kanker, anti-inflamasi, serta dalam penanganan sindrom ovarium polikistik (PCOS).
Buku ini hadir untuk menggali peluang-peluang baru dari metformin, memberikan wawasan ilmiah dan klinis yang dapat dimanfaatkan oleh peneliti, tenaga medis, maupun apoteker. Semoga buku ini menjadi kontribusi positif bagi pengembangan terapi berbasis metformin di masa depan.
Kata Pengantar.....................................................................................Iv
Daftar Isi................................................................................................v
Bab. 1 pendahuluan...............................................................................1
1.1 Sejarah dan Perkembangan......................................................2
1.2 Mekanisme Kerja.....................................................................3
Bab. 2 Farmakokinetik dan Farmakodinamik Metformin.....................4
2.1. Absorpsi, Distribusi, Metabolisme, dan Ekskresi...................4
2.2. Mekanisme Kerja dan Efek Farmakologi...............................6
Bab. 3 Metformin dan Kesehatan Kardiovaskular..............................12
Bab. 4 Metformin Sebagai Anti Inflamasi..........................................17
4.1 Metformin sebagai anti inflamasi..........................................17
4.2 Mekanisme Aksi Metformin dalam Proses Anti-Inflamasi...17
4.3 Bukti Klinis dan Preklinis Efek Anti-Inflamasi Metformin. .18
4.4 Potensi Klinis Metformin sebagai Agen Terapi Anti-Inflamasi
.....................................................................................................19
Bab. 5 metformin sebagai anti kanker.................................................20
5.1 Metformin Sebagai Anti Kanker............................................20
5.2 Mekanisme Aksi Metformin dalam Penghambatan Sel Kanker
.....................................................................................................20
5.3 Bukti Klinis dan Preklinis Penggunaan Metformin dalam
Terapi Kanker..............................................................................21
5.4 Penggunaan Metformin sebagai Adjuvan dalam Terapi
Kanker..........................................................................................22
vi
5.5 Tantangan dan Potensi Masa Depan Metformin dalam
Onkologi......................................................................................22
Bab. 6 Metformin dan Gangguan Metabolik Non-Diabetes...............24
6.1 Metformin dalam Terapi Sindrom Polikistik Ovarium (PCOS)
.....................................................................................................24
6.2 Metformin dan Penyakit Hati Berlemak Non-Alkohol
(NAFLD).....................................................................................27
6.3. Metformin dalam Manajemen Obesitas................................31
Bab. 7 Metformin dan Anti Penuaan...................................................34
7.1 Metformin sebagai Obat Anti-Penuaan.................................34
7.2 Efek Metformin terhadap Peradangan dan Stres Oksidatif...36
7.3 Studi Klinis Metformin dan Umur Panjang...........................38
Bab. 8 efek metformin pada neuerologi..............................................41
8.1 Manfaat Metformin Terkait Penyakit Alzheimer Dan Penyakit
Neurodegeneratif.........................................................................42
8.2 Efek Metormin Terhadap Parkinson......................................43
8.3. Metormin Terhadap Kesehatan Otak....................................44
Daftar Pustaka.....................................................................................48
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